Abstract
Summary: Percutaneous renal biopsy, an essential procedure for the evaluation of a patient with renal disease, has been improved by the use of semi‐automated, spring‐loaded renal biopsy guns. We have carried out a prospective, randomized study comparing the safety and tissue adequacy for histopathological diagnosis of renal biopsies performed under real‐time ultrasound guidance using the Biopty gun (Bard, Covington, GA, USA) and a 14 or 18 gauge needle on 103 native and 30 transplant kidneys. Repeat biopsy was necessary for only one renal transplant (0.75%) because of inadequate tissue. the biopsy procedure was well tolerated and complications (<5%) were uncommon in both groups. Biopsies of native kidneys with the 14 gauge needle required fewer attempts (3.23 vs 3.98; P= 0.005) and the cores obtained contained more glomeruli for light (24.8 in 2.78 cores vs 16.0 in 3.03 cores; P=0.0001) and immunofluorescence microscopy (9.5 vs 7.4; P= 0.01) than with the 18 gauge needle. Similarly, more glomeruli were obtained from transplant kidneys with the 14 gauge needle (19.5 in 1.19 cores vs 12.9 in 1.57 cores; P=0.004).
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