Abstract
Shielding of small portions of the hematopoietic system provides protection against the lethal effects of whole-body irradiation in the midlethal dose range. Transfusion of either whole blood or transplantation of hematopoietic tissues protects to some degree in every mammalian species studied.Manipulation of the radiation dose, time of transplant and recipient treatment with immune suppressors leads to some success in transplants between species. The probability of acceptance of an allograft is inversely related to the number of histocompatibility differences. Hence, in identical twins with no antigenic differences there should be 100% takes. Several investigators (1-4) have followed Atkinson (5) in attempting transplants between a normal individual and his whole-body irradiated leukemic identical twin. A logical extension of identical twin donor-recipient matching is the autologous transplant. The patient serves as donor and recipient with an interim treatment of radio or chemotherapy. This method has b...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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