Abstract
Estimates of myocardial blood flow (MBF) from first-pass contrast-enhanced cardiac magnetic resonance (CMR) imaging require accurate measurement of the arterial input function (AIF) from the left-ventricular (LV) blood pool. Both dual-bolus and dual-sequence CMR techniques have been proposed to maintain the linearity of the LV signal during the contrast passage.
Highlights
Estimates of myocardial blood flow (MBF) from firstpass contrast-enhanced cardiac magnetic resonance (CMR) imaging require accurate measurement of the arterial input function (AIF) from the left-ventricular (LV) blood pool. Both dual-bolus and dual-sequence CMR techniques have been proposed to maintain the linearity of the LV signal during the contrast passage
Quantitative MBF estimates were compared to microsphere reference using both AIF measurements. Both the dual-sequence CMR perfusion technique [1] and the dual-bolus protocol [2] were performed in five canines and 35 clinical subjects using a 1.5 Tesla scanner
Typical imaging parameters: 1 RR, 90° saturation pulse, 50°read out angle, saturation recovery 90 ms, TR 2.4 ms, TE 1.2 ms, matrix size 128x80
Summary
Estimates of myocardial blood flow (MBF) from firstpass contrast-enhanced cardiac magnetic resonance (CMR) imaging require accurate measurement of the arterial input function (AIF) from the left-ventricular (LV) blood pool. Both dual-bolus and dual-sequence CMR techniques have been proposed to maintain the linearity of the LV signal during the contrast passage. Purpose This study is to directly compare the AIF measured from dual-bolus and dual-sequence CMR techniques. Quantitative MBF estimates were compared to microsphere reference using both AIF measurements
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