Abstract
The effects of adrenaline, metaraminol, ephedrine and phenylephrine on myocardial irritability were evaluated in dogs at equivalent levels of isofiurane and halothane anaesthesia. The incidence of premature ventricular contractions associated with adrenaline and metaraminol infusions was significantly less during isoflurane anaes thesia, as compared with halothane. Ephedrine produced arrhythmias in approximately 50% of animals studied with both anaesthetics. Doses of adrenaline, metaraminol, and phenylephrine necessary to cause arrhythmias were greater during isoflurane anaes thesia. In addition, arrhythmias occurred at lower mean arterial pressures in all drug groups with halothane than with isoflurane anaesthesia.
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