Abstract
Objective : To Compare Argyrophilic Nucleolar Organiser Regions (AgNORs) pattern with Proliferating nuclear antigen (PCNA) in different grades of transitional cell carcinoma. Design : Descriptive and Comparative study. Material and Methods : A total of fifty transurethrally resected bladder tumour samples (TUR BT) were collected from Mayo Hospital, Lahore and Services Hospital, Lahore and processed for H&E, AgNOR stain and PCNA stain. The grading of tumours were made on H&E stain. While AgNOR pattern and PCNA labeling index were recorded for each case. Results : A significant higher proportion of cases (p<0.02) with 3+ AgNOR dispersion were seen in grade III tumours. The AgNOR proliferative index in grade III tumour was significantly higher (p<0.05) as compared with grade II tumours. The cases with AgNOR dispersion of 3+ had significantly higher mean PCNA labeling index (p<0.02) when compared tumours of 2+ AgNOR dispersion. Conclusion : AgNOR and PCNA have significant role in grading of transitional cell carcinoma. The demon-stration of AgNOR dispersion is also a simple and cost effective procedure and could be considered as a substitute for PCNA labeling index. Key words: Nuclear organizer regions, PCNA, Transitional cell carcinoma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
