Abstract
Recent studies have revealed that aortic valve diseases are associated with the increased incidence of the aortopathy development. However, the influence of aortic valve diseases on aortic hemodynamics remains unclear. The purpose of this study was therefore to investigate the hemodynamic differenecs in patients with and without aortic valve disease through patient-specific simulations performed on two aorta models (BAV with severe stenosis vs. normal tricuspid aortic valve (TAV)). Realistic geometries and boundary conditions were obtained from computed tomography angiography (CTA) and phase-contrast magnetic resonance imaging (PC-MRI) measurements, respectively. In addition, 4D-MRI were performed to validate the the numerical methods used to simulate transient flow characteristics. Obtained results shown that the 3D streamlines in the patient with normal TAV were relatively symmetric and evenly distributed. For the patient with BAV, concentrated and high-speed inflow jets were found to impinge on the ascending aorta accompanied by strong vortices. These results indicate that the aortic valve phenotype plays a crucial role in featuring the disturbed flows primarily in ascending aorta, which may relate to the development of aortic diseases.
Highlights
Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation affecting 1-2% of population and highly associated with congenital abnormalities of the aorta and the proximal coronary vasculature [Fedak, Verma, David et al (2002)]
Compared with a normal tricuspid aortic valve (TAV) with three semilunar leaflets, BAVs are composed of two uneven leaflets, normally with fused commissure in the large leaflet
Patient-specific geometries and boundary conditions were obtained from computed tomography angiography (CTA) and magnetic resonance imaging (PC-MRI), respectively
Summary
Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation affecting 1-2% of population and highly associated with congenital abnormalities of the aorta and the proximal coronary vasculature [Fedak, Verma, David et al (2002)]. Compared with a normal tricuspid aortic valve (TAV) with three semilunar leaflets, BAVs are composed of two uneven leaflets, normally with fused commissure in the large leaflet. Hemodynamic simulations were performed on two aorta models to. MCB, vol., supplemental 1, pp.71-72, 2019 quantitatively evaluate to what extent the aortic valve diseases ( BAV with severe stenosis vs normal TAV) would affect the aortic hemodynamics. Patient-specific geometries and boundary conditions were obtained from computed tomography angiography (CTA) and magnetic resonance imaging (PC-MRI), respectively
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