Abstract
To compare the anterior segment parameters of patients with pseudoexfoliation syndrome, patients with pseudoexfoliation glaucoma, and normal subjects. This prospective, controlled, comparative study included 150 eyes of 150 patients. The patients were divided into the pseudoexfoliation syndrome group, the pseudoexfoliation glaucoma group, and the control group (50 patients in each group). Axial length, central corneal thickness, aqueous depth, anterior chamber depth, lens thickness, K1 and K2 keratometry values, and white to white distance measurements were obtained by optical biometry and compared between the groups. The mean ages of the pseudoexfoliation syndrome, pseudoexfoliation glaucoma, and control patients were 62.18 ± 6.21, 61.80 ± 6.62, and 59.40 ± 6.89 years, respectively. There were no statistically significant differences between the groups in mean age or sex ratio (p>0.05). Mean central corneal thickness was statistically significantly greater, mean aqueous depth and anterior chamber depth were statistically significantly greater, and mean lens thickness was statistically significantly less in the control group than in the pseudoexfoliation syndrome and pseudoexfoliation glaucoma groups (p<0.05). Pairwise comparisons of the pseudoexfoliation syndrome group and the pseudoexfoliation glaucoma group revealed that there were no significant differences between these two groups in central corneal thickness, aqueous depth, anterior chamber depth, and lens thickness (p>0.017). Patients with pseudoexfoliation glaucoma and pseudoexfoliation syndrome had greater lens thickness, shallower aqueous depth and anterior chamber depth, and less central corneal thickness than normal subjects. None of the anterior segment parameters differed between patients with pseudoexfoliation syndrome and patients with pseudoexfoliation glaucoma.
Highlights
Pseudoexfoliation syndrome (PXS) is a systemic disease that is frequently seen in older people[1]
PXS affects all parts of the eye, especially the anterior segment, by the accumulation of pseudoexfoliation material (PXM)[2,3,4,5]
It is a risk factor for many clinical entities, such as small pupil, cataract, and zonular laxity, but the most frequent and important clinical condition associated with the syndrome is pseudoexfoliation glaucoma (PXG), which is more aggressive than primary open-angle glaucoma (POAG)[2,3,4,5]
Summary
Pseudoexfoliation syndrome (PXS) is a systemic disease that is frequently seen in older people[1]. Cataract formation, poor pupillary dilatation, blood-aqueous barrier impairment, zonular dialysis, lens subluxation, and both intraoperative and postoperative complications of cataract surgery are frequently associated with PXS[2,3,4,5,6]. New technologies in anterior segment imaging systems provide useful information for the diagnosis of many diseases[10,11]. Noncontact biometers use low-coherence reflectometry methods and can be used for some anterior segment measurements, such as central corneal thickness (CCT), aqueous depth (AD), anterior chamber depth (ACD), lens thickness (LT), axial length (AL), K1 and K2 keratometry, and white to white distance (WTW)(12,13)
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