Abstract
Purpose To compare central corneal thickness (CCT), aqueous depth (AQD), and anterior chamber depth (ACD) measurements using the swept-source (CASIA SS-1000, Tomey, Japan) and time-domain (Visante, Carl Zeiss Meditec, USA) anterior segment optical coherence tomographers (OCT) in normal eyes. Methods Sixty-eight eyes of 68 subjects were included. Three consecutive scans of each subject were obtained using both devices in a random order by one experienced operator. Standard deviation (Sw), coefficient of repeatability (CoR), coefficients of variation (CoV), and intraclass correlation coefficients (ICC) were used to evaluate the intraoperator repeatability. Agreement was assessed using the Bland–Altman plots and 95% limits of agreement (LoA). Results All measurements of the swept-source OCT (SS-OCT) and time-domain OCT (TD-OCT) showed high repeatability with low CoR (CCT: 2.34 μm and 6.16 μm; AQD: 0.05 mm and 0.09 mm; ACD: 0.06 mm and 0.09 mm), low CoV (CCT: 0.16% and 0.42%; AQD: 0.61% and 0.97%; ACD: 0.53% and 0.83%), and high ICC (>0.98). The mean CCT with SS-OCT was slightly thicker than the results with TD-OCT (difference = 4.55 ± 2.62 μm, P < 0.001). There was no statistically significant difference in AQD or ACD measurements between the two devices (0.01 ± 0.05 mm, P=0.111; 0.02 ± 0.05 mm, P=0.022, respectively). The 95% LoA between the SS-OCT and TD-OCT were −0.59 to 9.69 μm for CCT, −0.10 to 0.12 mm for AQD, and −0.09 to 0.12 mm for ACD. Conclusions High levels of repeatability and agreement were found between the two devices for all three parameters, suggesting interchangeability. SS-OCT demonstrated superior repeatability compared with TD-OCT.
Highlights
Accurate and precise biometry is essential for cataract and refractive surgery planning
Optical coherence tomography (OCT) is a noninvasive biometric technique which was first described by Huang et al [6] and was introduced in clinical practice in 1996 to measure retinal thickness [7]. e first commercially available OCT device designed for anterior segment measurement was a time-domain OCT (TD-OCT)
intraclass correlation coefficients (ICC) values were greater than 0.98 for both devices. e coefficient of repeatability (CoR) and coefficients of variation (CoV) values for Central corneal thickness (CCT), aqueous depth (AQD), and Anterior chamber depth (ACD) measured by TD-OCT were more than 2.6 times, 1.5 times, and 1.5 times that of swept-source OCT (SS-OCT), respectively, indicating better repeatability with the SS-OCT for all three parameters
Summary
Accurate and precise biometry is essential for cataract and refractive surgery planning. E CoR and CoV values for CCT, AQD, and ACD measured by TD-OCT were more than 2.6 times, 1.5 times, and 1.5 times that of SS-OCT, respectively, indicating better repeatability with the SS-OCT for all three parameters.
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