Comparison of Analgesic effect of Dexmeditomidine and Paracetamol as Adjuvant with Lignocaine Hydrochloride for Intravenous Regional Anesthesia

Abstract

Objective: To compare and evaluate the analgesic effect of Dexmeditomidine and Paracetamol as adjuvant with lignocaine hydrochloride following upper limb surgeries. Study Design: Quasi-experimental study Place and Duration of Study: Combined Military Hospital, Rawalpindi, Allied Hospital, Faisalabad, Fauji Foundation Hospital, Rawalpindi Pakistan Methodology: Sixty ASA physical status I and II patients undergoing upper limb surgery were included in this study. Patients were divided into three groups (n=20) in each group. Regional anesthesia was achieved with 3mg/kg of Lignocaine hydrochloride(L) (02%) in Group A (n=20). Group B received 3 mg/kg of Lignocaine hydrochloride plus Dexmedetomidine (D/L) 0.5 μg/kg. Group C (n=20) received 3 mg/kg of lignocaine hydrochloride plus 300 mg of paracetamol (P/L). Onset and recovery time of Sensory and motor blocks and post-operative pain using visual analogue score was evaluated. Results: Group B showed significantly less sensory block onset time and motor block onset time as compared with Group Aand Group C. Similarly, sensory block recovery time and motor block recovery time were significantly more in Group B compared to other groups. visual analogue score was significantly less in Group B in comparison with Group A and C. First postoperative analgesic request time was significantly longer in the Group B than in Group C. Conclusion: It was concluded that Dexmedetomidine/Lignocaine hydrochloride provides better analgesia compared to paracetamol/Lignocaine hydrochloride in intravenous regional anesthesia.