Abstract
Among the skin tumors, intracutaneous cornifYing epithelioma and well-differentiated squamous cell carcinoma are .s'imilar. The purpose of this study was to compare the immunostainingfor proliferating cell nuclear antigen (PCNA) clone PC i O, interphase nucleolar organizer regions staining (AgNORs) methods and mitotic index in these tumorso JıIve intracutaneous cornifYing epitheliomas in the dogs and 20 well-differentiated squamous cell carcinomas in various species were chosen. All sample.~ were .fixed in formalin and embedded in parapin. The mean number ofAgNOR was determined in 50 basal and 50 suprabasal cells of each tumor under an oil immersion lens at a magnification of 10()O.PCNA-Iabeledfractions and mitotic index were estimated in the same areas of these tumors in JO high power fields. AgNOR count (p < O,OJ) was significant, but peNA index and mitotic index were not significant in Mann-Whitney U test to compare intracutaneous cornifYing epithelioma and well-differentiated squamous cell carcinoma.
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