Abstract
Background: No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression. Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients. The administration of drugs such as antidepressants, antipsychotics, mood stabilizers do not seem to have affected the results. Conclusion: In patients of major monopolar depression age and gender differences of plasma levels of tryptophan metabolites disappear although significant differences are observed in healthy volunteers. Some differences of age and gender differences were shown between monopolar and bipolar depressive patients.
Highlights
No research has been done for the determination of plasma levels of tryptophan metabolites in patients of monopolar and bipolar depression
Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients
No significant age and gender differences were shown in monopolar depressive patients and some differences were shown in bipolar patients
Summary
22.8% of the global burden of diseases is due to psychiatric disorder [1]. Depres-. Using a meta-analysis of data of the effectiveness of antidepressants, it has recently been shown that all antidepressants are more effective than placebo in adults with major depressive disorders [3]. We have recently succeeded in the simultaneous measurements of all the TRP metabolites in plasma [5] [6] [7] [8]. Using this technology we measured all TRP metabolites in plasma of depressive patients. Since there are significant gender and age differences in plasma levels of TRP metabolites in healthy volunteers, we decided to analyze differences of TRP metabolites in patients of major monopolar depression and bipolar depression
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
