Abstract
1. 1.|Adenylate kinase (EC 2.7.4.3) activity of the liver and hindleg muscle has been compared in normal and dystrophic mice. 2. 2.|The total activity and specific activity of the muscle enzyme was greatly reduced in the dystrophic animals but the properties of the enzyme as estimated by its sensitivity to pH, temperature and dithiol reagents were unaffected by the disease. The dystrophic enzyme was slightly less stable on storage probably due to changes in the dystrophic muscle. 3. 3.|The properties of the liver enzyme were very different from the muscle enzyme with respect to these criteria. 4. 4.|Electrophoresis on starch and polyacrylamide gels showed tissue specific isoenzyme patterns which remained unchanged in the dystrophic samples. 5. 5.|It is concluded that, unlike the human enzyme, mouse muscle enzyme remains qualitatively unchanged in the dystrophic animals. 6. 6.|The differences between mouse adenylate kinases and those of other species are discussed.
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