Comparison of ADC Value and Prognostic Factors in Invasive Ductal Carcinoma

Abstract

Objective: Aim of this study is to investigate whether there is a correlation by comparison of apparent diffusion coefficient (ADC) in invasive ductal carcinoma patients whom magnetic resonance imaging (MRI) was performed before surgery with prognostic factors such as tumour grade, estrogen/progesterone receptors (ER/PR), HER2/neu (c-erbB-2 protooncogene), level of Ki-67. Methods: We retrospectively reviewed breast MRI in our radiology department between 2015 and 2017. The patients in whom diagnosed as not otherwise specified invasive ductal carcinoma (NOSIDC) after tru-cut biopsy and had preoperatively performed MRI were included in this study. Results: The retrospective review yielded 27 patients and evaluated ADC value in 30 lesions. Mean ADC value of lesions was 0,911x10-3mm2 /s (0,456-1,30x10-3mm2 /s) and mean ADC value of normal breast parenchyma was 1,613x10-3mm2 /s (1,116-2,453x10- 3mm2 /s). Statistically significant difference was not found between grade 1 (1 lesion), grade 2 (19 lesions), grade 3 (10 lesions), ER positive (25 lesions), ER negative (4 lesions), PR positive (1 lesion), PR negative (8 lesions), HER2 negative (21 lesions), HER2 positive (8 lesions) cases (grade; p=0.074, ER; p=0.57, PR; p=0.66, HER2; p=0.58). Mean ADC value was 0,855x10-3mm2 /s (0.660-1.30 x10-3mm²/s) in lesions of high Ki-67 proliferative index (20 lesions) and was 1,040x10- 3mm2 /s (0.985-1.70 x10-3mm²/s) in lesions of low Ki-67 proliferative index (5 lesions). Statistically significant difference between these two groups was found (p=0.007). Conclusion: In our evaluated prognostic factors, correlation with ADC value was found only in Ki-67 proliferative index and statistically significant difference was not found in the others.