Comparison of acute phase reactant pentraksin-3 and inflammatory parameters in acute and stable pulmonary embolism

Abstract

<b>Introduction:</b> Pulmonary thromboembolism; It is an obstructive disease of the pulmonary arterial system in different degrees and localization as a result of embolization of thrombi or non-thrombus substances. Pentraxin 3(PTX-3) is a member of the pentraxin family, in the same family as C-reactive protein. Our aim in this study reveals that the plasma PTX-3 level in PTE patients may be closely related to the prognosis of the disease as well as the diagnosis of PTE. <b>Method:</b> At the time of diagnosis, demographical characteristics and lab findings&nbsp;after 3 months of antikoagulant treatment have been saved of the patients that been studied. 5 cc plasma was taken from the patients who participated in the study at the time of diagnosis and from the 3rd month routine controls and from the control group for PTX-3 study and stored at -80 degrees. <b>Findings:</b> From a total of 74 patients in accordance with the study protocol( 50 patients;24 control group). From the patients who used anticoagulants for 3 months, 35 patients came for the second visit, 4 died, 11 patients left the study.&nbsp;A meaningful increase in PTX-3 levels was detected in the patient group(0.46 ng/ml) compared to the control group (0.21 ng/ml)( p;0.050).There was no meaningful change in PTX-3 levels when comparing the results at the first diagnosis with the control results performed after the 3rd month of the patients diagnosed with PTE. <b>Conclusion:</b> It shows that a significant increase in PTX-3 level in the patient group compared to the control group, which have proven usefulness and prognostic significance in the diagnosis of PTE&nbsp;at the time of theinitial diagnosis, could be helpful on diagnosis in situations that PTE suspected