Abstract
Sera from 192 children participating in studies of a pertussis toxoid vaccine were analyzed by enzyme-linked immunosorbent assay (ELISA) for pertussis toxin IgG antibodies and by the Chinese hamster ovary cell assay for pertussis toxin neutralizing antibodies. A significant linear correlation was found between titers obtained by ELISA and the neutralization assay ( r = 0.84, P < 0.0001). The study shows that these two assays give similar information for groups of sera, although an antibody titer obtained by one method could generally not be used to predict a titer for the other method with accuracy in an individual serum. We propose that ELISA alone can be used in studies of IgG antibody response to pertussis toxin after vaccination with pertussis toxoid.
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