Abstract

The reported incidence of aspirin resistance or non-responsiveness ranges between 5 and 30% [1]. There is neither a uniformly accepted definition of aspirin resistance nor an established standard method to assess aspirin non-responsiveness in the laboratory. The PFA-100™ has been most often used to assess aspirin effect. Aspirin non-responsiveness by the PFA-100™ is defined as an absence of a prolongation of the Collagen–Epinephrine cartridge closure time [2]. The second most widely used method is Born's optical platelet aggregometry, a labor intensive, time-consuming method that requires technical expertise.

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