Abstract
CONCLUSIONS The 3-step acne system is an effective antibiotic-free approach to the treatment of acne. Compared with a combination BPO/clindamycin product, the acne system is at least as effective in reducing the noninflammatory lesion count and may enhance the speed at which these lesions are reduced. The acne system also demonstrates comparable efficacy against inflammatory lesions and comparable tolerability. Its potential for a more rapid onset of action against non-inflammatory lesions is likely attributable to the improved solubilization of BPO enhancing the bioavailability and intrafollicular penetration of the BPO. The unique solvent technology employed in the BPO formulation might also play a role in enhancing efficacy in the early weeks of treatment.
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