Abstract
BackgroundClinical outcomes of new-generation drug-eluting stents (DES), Everolimus-eluting stent (EES) or Resolute zotarolimus-eluting stent (R-ZES), have been reported. However, angiographic follow-up data of new-generation DES are limited, especially in Asians. We investigated the angiographic and clinical outcomes of EES and R-ZES in a real-world setting of Korean patients.MethodsAngiographic and clinical outcomes of 679 patients (866 lesions) who had been treated with EES or R-ZES from Jun 2008 to May 2010 were evaluated. The primary analysis was to compare in-segment late loss at 9 months and the secondary analyses were to compare the clinical outcomes.ResultsIn-segment late loss at 9-month follow-up angiography was 0.23 ± 0.52 mm for EES and 0.29 ± 0.64 mm for R-ZES (p = 0.248). In addition, the rate of binary restenosis did not show between-group differences (5.8% vs. 6.8% for EES and R-ZES, respectively, p = 0.716). During a median follow-up of 33 months, there were no significant differences in Kaplan-Meier estimates of target lesion failure (TLF) (7.5% vs. 7.9% for EES and R-ZES, respectively, p = 0.578) and patient-oriented composite outcomes (POCO including all-cause death, any myocardial infarction, and any revascularization, 22.8% vs. 20.1%, p = 0.888). The adjusted hazard ratios for TLF and POCO were 0.875 (95% CI 0.427 - 1.793; p = 0.715) and 1.029 (95% CI 0.642 - 1.650; p = 0.904), respectively, for EES over R-ZES in the propensity score matched group analysis.ConclusionsIn Korean patients undergoing new-generation DES implantation for coronary artery disease, EES and R-ZES showed similar angiographic outcomes at 9 months and comparable clinical outcomes during 2.8 years of median follow-up.
Highlights
Clinical outcomes of new-generation drug-eluting stents (DES), Everolimus-eluting stent (EES) or Resolute zotarolimus-eluting stent (R-ZES), have been reported
Patients population From June 2008 to May 2010, we prospectively identified 734 patients who were treated by percutaneous coronary intervention (PCI) with either EES or R-ZES for chronic stable coronary artery disease or acute coronary syndrome, including myocardial infarction (MI) with or without ST-segment elevation
Of the remaining 1,327 patients who were treated with DES, 734 patients (55.3%) were treated with EES or R-ZES
Summary
Clinical outcomes of new-generation drug-eluting stents (DES), Everolimus-eluting stent (EES) or Resolute zotarolimus-eluting stent (R-ZES), have been reported. DES with a new-generation polymer were developed, including the Xience VTM everolimus-eluting stent (EES) (Abbott CardioVascular, CA, USA) and the Resolute zotarolimus-eluting stent (R-ZES) (Medtronic CardioVascular, CA, USA). These stents use a cobalt chromium based strut with permanent but biocompatible polymers (poly-vinyl-idene fluoride-co-hexafluoropropylene [PVDF-HFP] and Biolinx, respectively).[9] Recently, results of large scale randomized controlled trials (RCTs) with an ‘all-comers’ design have been reported comparing the efficacy and safety of EES and R-ZES [10,11,12]. The purpose of this study was to evaluate and compare the angiographic and clinical outcomes of EES and R-ZES in the unselected Korean patient population
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
