Abstract

Previous studies have reported a 20—30% reduction of climacteric symptoms with placebo and additional reductions of 10—20% using soy preparations providing 30—104 mg/day of isoflavones. However most studies were based on data from postmenopausal women. Their hormone status was quite different when compared to women undergoing menopause transition (MT). A single center prospective and randomized study was conducted to investigate the effect of insoflavone supplements with different doses in climacteric symptoms in women undergoing MT. After initial screening 48 women were recruited and assigned to two groups 35 mg and 70 mg groups with treatment duration of 6 weeks. Isoflavone supplements were prepared from soy extract in 325 mg capsules containing 17.5 mg of isoflavones per capsule (Phyto Soya Arkopharma Laboratories Pharmaceutique France). Modified Greene’s climacteric scale with three additional symptoms (frequency incontinence and vaginal dryness) was used to assess climacteric symptoms. (excerpt)

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