Abstract
Background: A simple laboratory method to evaluate relative potency of inhaled corticosteroids in asthma would be valuable. Single-dose studies with the allergen-induced late asthmatic response have failed to show a useful dose-response relationship. Treatment for several days with inhaled corticosteroids will also inhibit the allergen-induced early asthmatic response. Methods: Twelve atopic asthmatic subjects were studied during a season when no medications were required except ipratropium bromide as needed. These subjects had positive allergen and methacholine inhalation tests and FEV 1 greater than 70% of predicted value. A double-blind, randomized, cross-over study compared placebo and budesonide 100, 200, and 400 μg administered by means of Turbuhaler twice daily for 7 days with 6-day washout periods. Methacholine PC 20 was measured before and after 6 days of treatment, and allergen PC 15 was measured after 7 days of treatment. Results: The allergen PC 15 ( n = 11) was significantly larger ( P = .0001) for all doses of budesonide compared with placebo, but there was no significant difference between the 3 doses of budesonide, and no dose response was demonstrated. The methacholine PC 20 was significantly larger after all budesonide treatments compared with placebo ( P = .024), but there was no difference between the 3 doses. There was a progressive increase in the allergen PC 15 chronologically (sequence effect) that was not explained by improvement in FEV 1 or airway responsiveness; sequence effects were not seen for FEV 1 or for pretreatment or posttreatment methacholine PC 20. Statistical adjustment for sequence effect did not alter allergen PC 15 statistics. Conclusion: A 7-day course of budesonide administered by means of Turbuhaler at 200, 400, or 800 μg per day provided marked and significant inhibition of the allergen-induced early asthmatic response compared with placebo. There was, however, no difference between the 3 doses. Therefore this method with these doses is not useful for providing assessment of relative potency. (J Allergy Clin Immunol 1998;102:363-7.)
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