Abstract
2- and 3- 18F-fluoro-deoxy- d-glucose were proposed as sugar analogs to study glucose metabolism in brain and heart tissues. To evaluate their usefulness, the in vivo behavior of 2- 28FDG and 3- 18FDG was investigated in mice and rats and for 3- 28FDG in dogs at various times post-injection. Positron emission tomographic (PET) imaging was performed for heart and brain of anesthetized dogs with both radiopharmaceuticals. In all species studied, a higher uptake in brain, heart and kidney was observed for 2- 18FDG compared with 3- 18FDG. Radioactivity also cleared blood and liver more rapidly with 2- 18FDG than with 3- 18FDG. Estimates of brain kinetic model parameters revealed the metabolic trapping of 2- 18FDG, making this agent favorable for studies of tissue metabolism, and the relative lack of phosphorylation of 3- 18FDG, which makes it a potential agent for studies of glucose transport.
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