Abstract
The effects of α-MSH and several other vasoactive substances on the mesenteric vascular bed were studied in the anesthetized cat under conditions of controlled blood flow. Intra-arterial injections of α-MSH in doses of 10, 30, and 100 μg resulted in significant dose-related decreases in mesenteric arterial perfusion pressure but little or no effect on systemic arterial pressure. The vasodilator response to α-MSH was brief in duration and resistance to flow was decreased 10, 18, and 26 percent at 10, 30, and 100 μg. These significant changes after α-MSH were of a much smaller magnitude than were observed after prostaglandins E 1 and E 2, isoproterenol, bradykinin or glyceryl trinitrate and differed completely from the increased resistance after angiotensin II and norepinephrine.
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