Abstract
Objective: Preeclampsia characterized systematically by extensive vascular endothelial dysfunction and microangiopathy on mother, dNK is very important for the success of placentation. They are the key mediator of maternal immune system interactions with fetal cells. dNK cells are also involved in the modulation of EVT and the remodeling of spiral arteries.
 Methods: Analytic research with cross-sectional study, with samples of pregnant women who suffer from severe PE and aterm pregnancy which came to H. Adam Malik Hospital and Networking Hospital, November 2015-April 2016. The samples are 46 women, who met the inclusion criteria.
 Results: Immunohistochemistry examination dNK cell in the severe PE case group and control group, statistically found p<0,05. dNK placenta expression in the severe preeclampsia case group gives an overview of expression with a mean of 2.55±2.31, while the control group of normal pregnancy had higher mean is 8.66±3.16.
 Conclusion: The examination of immunohistochemistry of dNK cells showed there is a significant difference in the expression of Immuno-histochemistry dNK cells between severe PE case group and non severe PE.
Highlights
Preeclampsia is systemically characterized by widespread vascular endothelial dysfunction and microangiopathy in the mother, but not in the fetus
The results of this study found that the results of immunehistochemistry decidual natural killer (dNK) cells examination in the severe preeclampsia case group generally gave a description of expression with a mean of 2.55±2.31 while in the normal pregnancy control group had a higher mean with 8.66±3.16
Obtained p value
Summary
Preeclampsia is systemically characterized by widespread vascular endothelial dysfunction and microangiopathy in the mother, but not in the fetus. Knowledge of cellular and molecular processes of human trophoblast invasion is based on in vitro research and animal models; there is evidence that decidual natural killer (dNK) cells are very important in successful placentation. They are key mediators of the interaction of the mother's immune system with fetal cells. DNK cells are involved in modulation of invasion of extravillous trophoblasts (EVT) and remodeling of the maternal spiral arteries They express various surface receptors and signaling molecules, including cytokines, chemokines, and growth factors, and their function in modulating EVT migration, invasion, and change from epithelial phenotype to endothelial are beginning to be revealed [6]
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