Abstract
BackgroundThis was a prospective study to evaluate the effect of multilevel vertebral augmentation in addition to conventional therapy in multiple myeloma patients.MethodsWe treated 27 patients, whom were recently diagnosed to have multiple myeloma by two ways of treatment. Thirteen patients (group I) were treated with conventional therapy and 14 patients (group II) with adding vertebroplasty and kyphoplasty. Patients were evaluated pre-treatment and at half, one, two and 3-years post-treatment by using Oswestry Disability Index (ODI), the Stanford Score (SS) and the Spinal Instability Neoplastic Score (SINS).ResultsMean values of ODI, SS and SINS were 31.9 (63.8%), 4.3 and 13.8 for group I and 33.2 (66.4%), 4.6 and 12.8 for group II before starting treatment. Group II showed improvement better than group I at all follow-up intervals with best results at first 6 months. P-values at the end of the study were ODI = 0.047, SS = 0.180 and SINS = 0.002. Mortality rates were equal of both groups (four patients of each group).ConclusionAdding vertebral augmentation to conventional therapy improves multiple myeloma patients’ quality of life, but didn’t affect the mortality rate.
Highlights
This was a prospective study to evaluate the effect of multilevel vertebral augmentation in addition to conventional therapy in multiple myeloma patients
The following prospective study evaluated the outcomes of our multiple myeloma patients who underwent multilevel vertebral augmentation in addition to conventional therapy. This is a prospective study of effectiveness of the addition of vertebral augmentation to conventional chemotherapy and radiotherapy in treating multiple myeloma patients
We treated 27 patients, whom were recently diagnosed with multiple myeloma
Summary
This was a prospective study to evaluate the effect of multilevel vertebral augmentation in addition to conventional therapy in multiple myeloma patients. Bone becomes week and easy to fracture, which may cause pain in the bone and inability to use the limb. In the spine, fractured vertebra causes pain, kyphotic or kyphoscoliotic deformity, compression of the spinal cord or cauda equina in addition to the general symptoms of multiple myeloma [1, 3]. General treatment of the disease includes radiotherapy, chemotherapy and bisphosphonate to decrease bone resorption in addition to analgesia, bed rest and bracing to treat pathological fractures [1]. Minimally-invasive vertebroplasty and balloon kyphoplasty are used as local treatment of the vertebral lesions to decrease pain and prevent or treat deformities [3,4,5].
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