Abstract
Determinations were made of the plasminogen activator activity (PA) of biopsy specimens of the great saphenous vein and at the same level of the femoral or the popliteal vein in 35 patients undergoing amputation of the leg because of arterial insufficiency and in one because of deep venous insufficiency. The PA was measured with a modification of Todd's fibrin slide technique. In 21 patients the PA was also determined in biopsy specimens of a muscle vein at the same level of the leg. The PA of the walls of superficial veins proved significantly lower than that of the walls of deep major veins. No difference in activity was demonstrable between muscle veins and deep major veins. A significant correlation was found between the PA of superficial and deep veins.
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