Abstract
Background and Objectives: The over production of gastric acid results in peptic ulcer. This study was done to compare the effects of thymoquinone and Verapamil on volume and acidity of carbachol induced gastric secretion.
 Methods: There were 24 rabbits used, weighing 1-1.5 kg. The rabbits were kept on fasting for 48 hours. After fasting, the pylorus of each rabbit was ligated. Thymoquinone 5 mg/kg, Carbachol 600mg/kg and Verapamil 10 mg/kg body weight were administered intraperitoneally. Pylorus ligation method was used for getting gastric contents and titration method was used for finding out acidity.
 Results: Verapamil has been proved very effective for the treatment of many diseases. The drug verapamil inhibits the release of histamine, acetylcholine and gastrin. Verapamil has also shown effects in reducing the secretion of gastric acid. It was found that Thymoquinone reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P=0.000) but when we compared the results of Thymoquinones with that of Verapamil, it was non-significant.
 Conclusions: It was concluded that Thymoquinone can be used for the treatment of peptic ulcer and all other diseases which are caused by increased gastric acidity like dyspepsia, gastritis and reflux esophagitis.
 Peer Review History: 
 Received 8 July 2020; Revised 14 August; Accepted 6 September, Available online 16 September 2020
 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.
 Received file 
 
 Average Peer review marks at initial stage: 6.0/10
 Average Peer review marks at publication stage: 8.0/10
 Reviewer(s) detail:
 Name: Dr. Hatem Sameir Abbas
 Affiliation: Al-Azhar University, Egypt
 E-mail: hsam8406@yahoo.com
 
 Name: Prof. Dr. Ali Gamal Ahmed Al-kaf
 Affiliation: Sana'a university, Yemen
 E-mail: alialkaf21@gmail.com
 
 Name: Dr. Gehan Fawzy Abdel Raoof Kandeel
 Affiliation: National Research Centre, Egypt
 E-mail: gehankandeel9@yahoo.com
 
 Name: Dr. Mahmut Yıldıztekin
 Affiliation: Muğla Sıtkı Koçman University, Turkey
 E-mail: mahmutyildiztekin@mu.edu.tr
 
 Comments of reviewer(s): 
 
 Similar Articles:
 COMPARISION OF ANTIDYSLIPIEMIC POTENTIAL OF 80 MILLIGRAMS OF FENOFIBRATED WITH 8 GRAMS OF NIGELLA SATIVA SEEDS DAILY 
 GC-MS ANALYSIS OF FIXED OILS OF NIGELLA SATIVA SEEDS 
 WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY
Highlights
Background and ObjectivesThe over production of gastric acid results in peptic ulcer
There was a reduction in all the volume, free and total acidity of Verapamil+ Carbachol parameters and was found to be highly significant group to those of Thymoquinone + Carbachol group, p when compared with Carbachol group (P=0.000)
It was found that this study is reported to show significant response as concluded by other scientists who found that calcium channel blocker Verapamil significantly reduces gastric acid secretion[22,23]
Summary
Peptic ulcer is one of the most common medical complain. In majority of the patients, peptic ulcer is caused by elevated acid production from gastric mucosa. Because of the large variety of uses of Nigella sativa, many researchers have conducted various in vitro and in vivo studies on laboratory animals and human beings in order to find out their pharmacological activities. These include antiinflammatory[3], analgesic, anti-pyretic activity[4], antimicrobial[5,6,7,8], antifungal[9,10,11], hypoglycemic[12] and anti-tuberculosis[13]. Thymoqui-nione administration can prevent and improve the murine-DSS (dextran sodium sulfate) induced colitis It could serve as an effective therapeutic agent for the treatment of patients with inflammatory bowel disease. It helps to prevent colitis and diarrhea in patients[14]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
