Comparison between Tamsulosin and Tadalafil Versus Tamsulosin alone to treat Lower Ureteric Stones Through Medical Expulsive Therapy: a comparative study

Abstract

Aim: To compare between Tamsulosin and Tadalafil versus Tamsulosin alone to treat Lower Ureteric Stones through Medical Expulsive Therapy Study design: Comparative study Place and duration: This study was done at Ghulam Muhammad Mahar Medical college hospital Sukkur, Pakistan from February 2021 to July 2021. Methodology: This study was carried our in our institute for 6 months. Patients that were having stones of 5mm to 10mn were included in the study, because these stones are detected easily through CT scans and ultrasound. Patients were randomly divided into two groups each containing 86 persons. Prescription of tamsulosin of 0.3 mg and tadalafil of 8 mg was given to group A patients and 0.3mg, tamsulosin was prescribed to group B Results: The stone expulsion rate was 78.0% in group A and 61.5% in group B. The stone passage time was 1.55 vs. 2.22 weeks in group B. In 45 patients there was no stone expulsion at the end of 3rd week of treatment. So these patients were treated with laser lithotripsy. A comparison study of two groups showed that group B has more episodes of flatulent pain than group A. The average need for analgesia was more in group B than group A. Conclusion: It is found from this study that tamsulosin alone is less effective than tamsulosin and tadalafil combination therapy and they both give fewer emergency room visits and require less pain killers for the treatment of 5mm and 10mm ureteric stones.