Abstract
The serum concentrations of the carboxy-terminal propeptide of type I procollagen (PICP) were monitored in 52 serum samples from 13 patients receiving renal transplants and the values compared with bone alkaline phosphatase (BAP) concentrations and intact parathyrin levels. There was a significant correlation between BAP and PICP values in all 52 serum samples examined ( r = +0.770; P < 0.0001). Before transplantation BAP ( P < 0.0001), but not PICP ( P < 0.1), was correlated with intact parathyrin levels. BAP concentrations increased from 7.3 ± 1.2 μg/l (median ± S.E.M.) before transplantation to 13.3 ± 1.2 μg/l 3 months after transplantation ( P < 0.01). There was a concomitant rise in PICP levels from 95 ± 19 μg/l to 166 ± 27 μg/l ( P <0.05). No correlation was found between BAP or PICP levels on the one hand and intact parathyrin concentrations on the other at any time following renal transplantation ( P < 0.5). In conclusion, PICP may be a useful parameter for monitoring bone formation following renal transplantation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
