Abstract
MERS (Middle East Respiratory Syndrome) is a worldwide disease these days. The number of infected people is 1038(08/03/2015) in Saudi Arabia and 186(08/03/2015) in South Korea. MERS is all over the world including Europe and the fatality rate is 38.8%, East Asia and the Middle East. The MERS is also known as a cousin of SARS (Severe Acute Respiratory Syndrome) because both diseases show similar symptoms such as high fever and difficulty in breathing. This is why we compared MERS with SARS. We used data of the spike glycoprotein from NCBI. As a way of analyzing the protein, apriori algorithm, decision tree, SVM were used, and particularly SVM was iterated by normal, polynomial, and sigmoid. The result came out that the MERS and the SARS are alike but also different in some way.
Highlights
Middle East respiratory syndrome (MERS) was first identified in Saudi Arabia since an outbreak of new flu in 2012
The respiratory infection is caused by MERS coronavirus (MERS-CoV), case of which have been reported in 25 countries including Saudi Arabia, Egypt, United Kingdom, United States, and South Korea. 1,211 infections and 492 deaths were reported so far, which means about 40% of those who infected die of the disease
The coronavirus infection begins with binding between receptor binding domains (RBDs) in S1 domain and receptor of the host cell, followed by viral fusion and entry resulted by the formation of fusogenic core between the HR1 and HR2 regions in S2 domain [6]
Summary
Middle East respiratory syndrome (MERS) was first identified in Saudi Arabia since an outbreak of new flu in 2012. The respiratory infection is caused by MERS coronavirus (MERS-CoV), case of which have been reported in 25 countries including Saudi Arabia, Egypt, United Kingdom, United States, and South Korea. 1,211 infections and 492 deaths were reported so far, which means about 40% of those who infected die of the disease. Since no specific vaccine and treatment of the virus were known as of 2015, the comparison of the virus with SARS coronavirus (SARS-CoV) has largely increased in the importance
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