Comparison between myeloperoxidase and high-sensitivity C-creative protein for predicting major adverse cardiovascular events in coronary heart disease patients

Abstract

Background: High-sensitivity C-reactive protein (hs-CRP) has been considered to be an independent predictor of adverse cardiovascular events. Myeloperoxidase (MPO) also plays an important role in atherosclerosis initiation and development of cardiovascular disease. Our objective was to compare the values between MPO and hs-CRP for predicting major adverse cardiovascular events (MACEs) in patients with coronary heart disease (CHD). Methods: A total of 201 patients with acute coronary syndrome (ACS) and 210 controls (non-ACS patients), whose variables of MPO, hs-CRP, metabolic parameters, anthropometrics and life style habits were analyzed with SPSS software. The incidences of MACEs were investigated during the 4-year period follow-up in 285 CHD patients. Results: Patients with ACS had significantly higher concentrations of MPO and hs-CRP than patients with non-ACS (P vs. no, odds ratio (OR) 7.383, 95% CI, 4.095–13.309] and high hs-CRP baseline concentration (yes vs. no, OR 4.186, 95% CI, 2.469–7.097). Conclusions: The present study has provided the valuable evidence that MPO has some advantages than hs-CRP for predicting MACEs. Elevated baseline MPO and hs-CRP concentrations are significantly associated with MACEs in CHD patients.