Abstract
Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the risk of developing cardiovascular diseases (CVD). Previous studies that compared FRS and MS have focused on high-income urban areas. This study focused on the comparison between FRS and MS when used in nomadic minorities in mountain areas. Moreover, an applicable tool for predicting the risk of developing CVD was identified. 2,286 participants who were recruited from the far west of China were followed-up for a median of 5.49 years. MS and FRS were compared in terms of their ability in predicting development of CVD using Cox regression and receiver operating characteristic curve. After each component of MS was appraised, its area under the curve (AUC) was 0.647. When age was included, the AUC of MS risk score increased from 0.647 to 0.758 (P < 0.001). After adjusting for age, the AUC of FRS decreased from 0.732 to 0.582 (P < 0.001). The association between CVD and each quintile of MS risk score that included age was more significant than that between FRS and CVD under the same exposed condition. In conclusion, MS risk score that included age may be a better predictor of CVD among Kazakhs.
Highlights
Suggested that Metabolic syndrome (MS) is inferior to the Framingham risk score (FRS) in predicting CVD3,21–25
A cohort study involving the Chinese population has found that the MS risk score was a valid tool for predicting cardiovascular diseases (CVD), and its predictive ability was as good as the FRS26
This study may help identify the appropriate methods to be used in the prevention of chronic diseases, such as CVD, in Kazakhs living in other countries, such as Kazakhstan and Uzbekistan
Summary
A cohort study involving the Chinese population has found that the MS risk score was a valid tool for predicting CVD, and its predictive ability was as good as the FRS26. These data cannot be extrapolated in Kazakh populations as their eating habits and living environment are different from other ethnic groups. We conducted a cohort study that compared the predictability of MS and the FRS for CVD to identify the most applicable and simple clinical tool in predicting the development of long-term CVD in the Kazakh population in Xinjiang, China. This study may help identify the appropriate methods to be used in the prevention of chronic diseases, such as CVD, in Kazakhs living in other countries, such as Kazakhstan and Uzbekistan
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