Comparison between mandibular and femur derived bone marrow stromal cells: osteogenic and angiogenic potentials in vitro and bone repairing ability in vivo

Wenhui Zhou,Jinkai Zhang,Fengshan Chen,Kaili Lin

doi:10.1039/c7ra07139f

Abstract

M-BMSCs contains stronger osteogenic and angiogenic potentials, and better bone repairing ability.

Highlights

Jaw defects are a common clinical manifestation originating from various diseases that will result in facial asymmetry, dysmasesia, and asophia, etc
F-bone marrow stromal cells (BMSCs) appeared aging at the 6th generation, while maxillofacial derived BMSCs (M-BMSCs) appeared no remarkable morphological changes (Fig. 1a)
From ow cytometric analysis and the real time polymerase chain reactions analysis (Fig. 1c and d), both MBMSCs and femur derived BMSCs (F-BMSCs) were positive for CD29 and CD90, while negative for CD45 and CD34

Summary

Introduction

Jaw defects are a common clinical manifestation originating from various diseases that will result in facial asymmetry, dysmasesia, and asophia, etc. Human jaw has great potential in regeneration, it is unpractical to expect that a large bone defect can be completely restored spontaneously. With many advantages in bone repairing over autogra and allogra , is widely used to repair large bone defects and to establish normal functions.[1,2,3] The goal of bone tissue engineering is to supply sufficient skeletal dimension through the basis of seed cells, biomaterials and growth factors. As one of the three basic elements of tissue engineering, biomaterials have been extensively investigated for decades;[4,5] while seed cells, another basic element, serve as the core of tissue engineering and need more attention from researchers.[6,7]

Methods

Results

Discussion

Conclusion