Abstract

The study aimed to compare the acetaminophen administration efficacy or its combination with codeine for pain control in acute apical abscesses cases. Thirty-nine patients who sought emergency treatment in the Faculty of Dentistry of the Federal University of Rio Grande do Sul were included, all of them with acute apical abscess diagnosis. These patients were divided into two groups: acetaminophen group-prescription of acetaminophen (1000mg) and acetaminophen-codeine group-prescription of acetaminophen (1000mg) + codeine (30mg), both with oral intake every 6h for 3days. The pain scores were recorded by the patients on their own at 6, 12, 24, 48, and 72h after finishing clinical assistance, by filling a pain evolution journal, containing a visual analogue scale (VAS). Student t test was conducted to investigate different mean ages between groups 1 and 2. A comparison of weight and means of initial pain scores between groups was carried out using the Mann-Whitney U test. Chi-square test was performed to compare gender, affected tooth, education, initial swelling, and frequency of adverse effect between test and control groups. Mann-Whitney U test was applied to compare groups in the same period. Friedman's test was used to compare results from the same group over time. Both groups showed score reduction over time (P < 0.05). Paracetamol-codeine group showed significant pain score reduction at 48h registers when compared to baseline and at 6h scores (P < 0.05). Further, pain scores at 72h were significantly lower, when compared to the baseline, at 6h, and at 12h scores (P < 0.05). Acetaminophen group showed significant pain score reduction observed at 72h, when compared to the baseline and at 6h scores (P < 0.05). There were no significant differences in pain score reduction over time between groups (P > 0.05). There was no difference between the groups regarding the frequency of adverse reactions (P > 0.05). Both medications were effective for pain control in acute apical abscess cases. The findings might have inferred in pain control of acute apical abscess associated pain in patients who used an antibiotic drug. External validity of the findings for acute apical abscess cases with no need for an antibiotic prescription is uncertain. This paper suggests acetaminophen 1000mg can be used for pain control in the treatment of acute apical abscess associated with systemic manifestation.

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