Abstract
The inhalational agents are very important to maintain the depth of anesthesia, provide analgesia and muscle relaxant. Many factors have effect of anesthetic gases, including type in an anesthetic agents and its MAC and other properties and postoperative stays. This study were designed to comparison between isoflurane and sevoflurane as inhalational agents on the pulse rate during general anesthesia.
 This prospective study were carried out at Baghdad Teaching Hospital, Medical City Complex, Baghdad/Iraq from 2nd January 2020 – 20th February 2020.
 Thirty (30) patients between 7 - 68 years old were enrolled in this study. Male was 13 and female was 17, in all selected patients, pulse rate was recorded at baseline, at intubation at 5 min, 10 min, 15 min, 20 min, 25 min, 30min, 40 min of the time of operation, extubation, and recovery.
 Results showed that the pulse rate at baseline there is not significant different in pulse rate of each gas, at intubation there is significant change in pulse rate, at 5 min ,10 min, 15 min, 20 min, 25 min, 30 min, 40 min, extubation, recovery there is not significant different in pulse rate.
Highlights
Inhalational anesthetics agents have been used for surgical anesthesia and analgesia, in 1954 Charles Suckling presented the first modern halogenated inhalational anesthetics agent, halothane [1]
Inhalational anesthetics agents have been used for surgical anesthesia and analgesia, all volatile anesthetics which cause dose-dependent effects on cardiovascular function especially PR, this study shows the effect of sevoflurane and isoflurane on the pulse rate in different intervals, Comparison of PR at baseline for each gas; there was a significant difference in PR at intubation, no significant difference at 5min,10min, 15min, 20min, 25min, 30min and 40min, extubation and recovery
Recent studies found there was a significant difference in PR at intubation when using both sevoflurane and isoflurane, it is may due to autonomic nervous stimulation during forced applied of laryngoscop or intubation sometimes lead to changes in hemodynamic parameters [9, 10]
Summary
Inhalational anesthetics agents have been used for surgical anesthesia and analgesia, in 1954 Charles Suckling presented the first modern halogenated inhalational anesthetics agent, halothane [1]. Sevoflurane and desflurane are the most modern contributors of inhalational agents [1,2] Regarding anesthetics agents, they attain in the alveoli and immediately pass through the alveolar sac, the bloodstream transmit the agents to all perfused organs [1,2]. Intravenous and inhalational anesthesia can affect cardiovascular execution; this includes effects on the rate of the heart, cardiac output, cardiac conduction system, systemic vascular resistance, blood pressures, myocardial contractility and even in the flow of blood in coronaries [5]. The uses of anesthetics volatile agent (e.g., halothane, sevoflurane, desflurane, and isoflurane) lead to dose-referred effects on cardiovascular stability. In compensation with nitrous oxide, isoflurane cause raises in the cardiac sympathetic action, but sevoflurane cause falls in cardiac sympathetic and parasympathetic action. The definition of pulse rate (PR) is the number of heart beats per minute and measured by pulse Oximetry, any decreasing of blood oxidation is critical in medicine, e.g. in surgical implementation and critical care, and may lead to death of cells and damage of the brain in a minute [6]
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