Comparison between Heidelberg retinal tomography-II and Heidelberg optical coherence tomography in diagnosis of pre-perimetric glaucoma

Abstract

Objective To compare the clinical value of Heidelberg retinal tomography (HRT-Ⅱ) and Heidelberg optical coherence tomography (HRA-OCT) in discriminating healthy eyes and pre-perimetric glaucoma eyes. Methods A total of 33 patients with pre-perimetric glaucoma and 37 healthy subjects were included in this study. All individuals underwent imaging tests with HRT-Ⅱ and HRA-OCT within 1-month period. ANOVA and Kruskal-Wallis test were used to compare all of the parameters from HRT-Ⅱ and HRA-OCT between pre-perimetric glaucoma eyes and normal eyes. Receiver operating characteristic curves (ROC) were calculated for all of the parameters to seek the best discriminant point of each instrument between pre-perimetric glaucoma and healthy eyes. Results Statistically significant differences were found in most of the HRT-Ⅱ parameters except for disc area and height variation contour between pre-perimetric glaucomatous eyes and normal eyes (all P 0.05). Conclusions Both HRT-Ⅱ and HRA-OCT can well reflect the damage of optic disc and retinal nerve fiber layer in eyes with pre-perimetric glaucoma. HRT-Ⅱ and HRA-OCT have higher accuracy and similar sensitivity and specificity for the diagnosis of pre-perimetric glaucoma. Key words: Retina; Visual fields; Glaucoma