COMPARISON BETWEEN C-REACTIVE PROTEIN AND SERUM LACTATE IN EVALUATION OF SEPSIS INDUCED ACUTE KIDNEY INJURY AND SEPSIS WITHOUT ACUTE KIDNEY INJURY

Abstract

Background One of the main causes of death in critically ill patients is sepsis. In Intensive care unit half of the patients develop Acute Kidney Injury, and has high mortality rates. In assessment of sepsis there are multiple markers in which C-reactive protein, serum lactate are commonly used. C-reactive protein is known biomarker of inammation and involved in several immunological functions. Aim To correlate C-reactive protein and Serum lactate in evaluation of sepsis induced acute kidney injury and compare these parameters in sepsis without acute kidney injury. Materials & Methods This is a Cross-sectional study which will be done at Mahatma Gandhi Medical College and Research Institute, Pondicherry. This study comprises of 52 patients out of which Group 1 are 26 patients having sepsis with AKI and Group 2 are 26 patients are having sepsis without AKI. Complete case history including the socio-demographic data and other medical conditions of the patient was recorded and & the collected blood samples were recorded for CRP, Serum lactate as well as other parameters. Results Mean age of subjects in sepsis with AKI and sepsis without AKI are almost similar, with 55.8 % being females. 90% of sepsis with AKI group and 76% of sepsis without AKI group has CRP of >10 and 42% of sepsis with AKI group and 34% of sepsis without AKI group has Lactate of >2. Conclusion CRP and Serum lactate are markers of inammation. CRP has been used to monitor the course of infection and inammatory diseases. CRP has not only a biochemical marker of inammation but also an active modulator of the inammatory response.