Comparison between BNP and NT-proBNP in pediatric populations

Abstract

BackgroundB-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are essential biomarkers for the evaluation of cardiac pathologies. However, pediatric reference intervals for BNP and NT-proBNP are not well defined and concordance between them in the evaluation of pediatric patients has been poorly described. MethodsPaired BNP and NT-proBNP testing was performed on 311 specimens representing 175 pediatric patients. Pediatric BNP and NT-proBNP reference intervals derived from the literature were used to evaluate concordance of results based on age group and cardiac pathology. ResultsDeming regression analysis of BNP and NT-proBNP results revealed a slope of 13.63 (95% CI, 10.35–16.92) and y-intercept of −977.8 (-2063–107.2) with a positive Spearman correlation (r = 0.91). By age group, concordance kappa between BNP and NT-proBNP was 1.0 for 0–10 days, 0.23 (0–0.62) for 11–30 days, 0.82 (0.67–0.97) for 31 days–1 year, 0.81 (0.57–1.0) for 1–2 years and 0.73 (0.64–0.86) for 2–18 years. The ratio of NT-proBNP to BNP was lowest in heart transplant patients (ratio, 6.5 [95% CI, 5.1–8.1]) relative to those with heart disease (10.5 [8.8–13.7]) and pulmonary hypertension (14.2 [11.3–16.0]) but no differences in concordance were observed. For serial specimens, 21% displayed inverse, discordant changes in BNP and NT-proBNP results. Review of discordant serial results revealed that kinetics of changes was comparable and unlikely to be clinically significant. ConclusionsThere is positive correlation and moderate concordance between BNP and NT-proBNP in the pediatric population studied.