Abstract
Decreased ovarian reserve is considered as one of the main causes of infertility. It is about the availability of preovulatory oocytes in the ovaries. With increase age, ovarian reserve decreases. Nowadays, “ovarian reserve” assessment became a strategy to assess female infertility.Objective: The current study aims to find the relationship between age and infertility type with measures of ovarian reserve (FSH, AMH and AFC) in infertile patients.Material and Method: The cross-sectional study design was used for this study and a survey was conducted among 100 infertile women.Result: Results revealed that Relationships between age and ovarian reserve indicators show a highly significant negative correlation with AFC (p= 0.001) and AMH (p= 0.007) level while positive correlation is found with FSH level (p= 0.001). The relation between age and FSH was moderate (rs=0.38, p<0.0001) and revealed that AMH and AFC level decreases while FSH level increases with age.Conclusion Study of AMH level is the most reliable source to measure age-specific changes.
Highlights
In the modern world, the determination of the strategy to manage female infertility by assessing ovarian reserve has become necessary
The relation between age and FSH was moderate and revealed that AMH and AFC level decreases while FSH level increases with age
As an ovarian reserve marker, AMH is useful to estimate the reproductive lifespan of healthy young women and to predict the ovarian response to stimulation for in vitro fertilization (IVF), namely poor and hyperresponses 8
Summary
The determination of the strategy to manage female infertility by assessing ovarian reserve has become necessary. AMH (Anti-Mullerian Hormone) or Mullerian inhibiting substance is promising marker for ovarian reserves. It is a dimeric glycoprotein and involved in growth and differentiation. For evaluation of low ovarian reserve, FSH and E2 levels were considered to be determining biochemical markers for several years. AFC is considered the first choice to determine ovarian reserve by several health care professionals because it predicts poor response effectively when compared to basal FSH. It has been suggested that Anti-mullerian hormone are essential in the evaluation of ovarian response. It is a Mullerian inhibiting hormone which is a dimeric glycoprotein. There are certain advantages of AMH when compared with other tests in the assessment of ovarian
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