Comparison and observation on chromosome telomeric associations in human lung cancer.

Abstract

To explore the regularity of abnormal telomeric associations in cellular chromosome of human lung cancer. The rate of telomeric associations was detected in human lung adenocarcinoma cell line A549 , peripheral blood lymphocytes in 15 patients with lung cancer , and in patients with non-cancerous diseases and normal adults as control by chromosome preparation assay. A highly significant difference in the rate of telomeric associations was found between lung cancer group and control group ( P < 0. 005) . Human lung adenocarcinoma cell line A549 had the highest rate of telomeric associations in all groups ( P < 0. 005) . Moreover , there was significant difference in the rate of telomeric associations in idiogramB , idiogram C and idiogram D between lung cancer group and control group (idiogram B , P < 0. 05 ; idiogram C , idiogram D , P < 0. 005) . Compared with control group , human lung adenocarcinoma cell line A549 and lung cancer chromosome has higher telomeric associations and most of themoccured in idiogramB , idiogram C and idiogram D. It will provide worthwhile data of cell genetics for further research work on early diagnosis and prognosis in human lung cancer.