Comparision of two new hemostatic dressings in controlling hemorrhage in a severe groin injury model in swine

Abstract

BackgroundHemorrhage is a leading cause of death from trauma. Polyacrylate Hemostatic Dressing (PHD) and Wrap Zeolite Hemostatic (WZH) are new hemostatic products touted to be effective in controlling severe extremity bleeding. This study compared the efficacy of two hemostatic dressings in a severe groin injury model in swine.MethodsTwelve swine received PHD and WZH for hemostasis. A reproducible femoral artery injury was created using a 6 mm aortic punch, and free bleeding was allowed for 5 seconds. The groin was packed with the randomized dressing followed by 2 minutes of manual compression. Hemostasis failure was defined as blood pooling outside the wound. Animals were monitored for 120 minutes. Endpoints were percent survival, survival time, blood loss and tissue histology.ResultsBaseline physiologic parameters were similar between groups. There were no differences in mortality was seen between groups. PHD resulted in less hemostasis failure (p < 0.05), decreased postcompression blood loss (p < 0.05). Histologic observations showed mild to moderate changes in treated vessels and muscles, WZH has caused more changes than PHD.ConclusionPHD performed significantly better than WZH in controlling hemorrhage from a severe groin injury in swine.This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.