Comparision of effect of pioglitazone and metformin in treatment of type 2 diabetes mellitus

Abstract

Objective To compare the effect of pioglitazone and metformin in dereasing blood glucose,blood fat and improving insulin sensitivity.Methods The parallel randomized control clinical trial was used.Sixty patients with type 2 diabetes mellitus were divided into treatment group and control group.The patients of control group took mefformin 500 mg,po,bid for 12 weeks.The patients of treatment group took pioglitazone 30 mg,po,qd for 12 weeks.The changes of blood glucose,blood fat and insulin before and after treatment between two groups were observed.Results The blood glucose and glycosy-lated hemoglobin (HbA1c) after treatment in two groups significantly reduced (P＜0.01).Insulin and C-peptide reduced in treatment group (P＜0.01).As to control group,postprandial insulin reduced (P＜0.05).The triglycerides and the free fat acid reduce in treatment group.However,the high-density lipoprotein cholesterol was improved in two groups(P＜0.01).Besides,the variable value of lower -density lipoprotein cholesterol and total cholesterol in control group was obviously lower than that in treatment group (P＜0.05).There was no difference in adverse reaction rate between two groups(P ＞ 0.05).Conclusions Pioglitazone and metformin are equal efficient in decreasing blood glucose and regulating blood lipid.Moreover,pioglitazone exerts significant effects on improving insulin sensitivity and reducing blood pressure. Key words: Pioglitazone; Metformin; Type 2 diabetes mellitus