Comparision effects of solifenacin, darifenacin, propiverine on ocular parameters in eyes: A prospective study

Mahmut Taha Ölçücü,Kerem Teke,Burcu Işık,Yusuf Cem Yilmaz,Mesut Toğaç,Kadir Yildirim

doi:10.1590/s1677-5538.ibju.2019.0094

Mahmut Taha Ölçücü, Kerem Teke + Show 4 more

Open Access

https://doi.org/10.1590/s1677-5538.ibju.2019.0094

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Abstract

ABSTRACTObjective To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD).Materials and Methods Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks.Results A total of 165 patients (330 eyes) with OAB were evaluated. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Propiverine (n=80) significantly increased PD from 4.04±0.48 mm to 4.08±0.44 mm (p=0.009) and 4.09±0.45 mm (p=0.001), at the fourth and twelfth weeks, respectively.Conclusion These findings can help to decide appropriate anticholinergic drug choice in OAB patients. We finally suggest further well-designed randomized prospective studies with a larger population to evaluate the anticholinergic-related complications in eyes.

Highlights

Both sexes are affected by an overactive bladder (OAB), which is a common disorder with a reported prevalence between 11.8% and 16.9%
M2 receptors are the most intensive muscarinic receptor types in the bladder and mostly M2 and M3 receptors play a role in OAB physiopathology [21]
It is known that darifenacin and solifenacin are more selective for M3 than M2 receptors [6]

Summary

Objective

To evaluate the effects of solifenacin, darifenacin, and propiverine on nasal-, subfoveal-, temporal choroidal thicknesses (NCT, SFCT, TCT), intraocular pressure (IOP) and pupil diameter (PD). Materials and Methods: Patients with overactive bladder (OAB) diagnosed according to The International Continence Society were administered with solifenacin, darifenacin or propiverine on a daily basis between November 2017 and May 2018. NCT, SFCT, TCT, IOP, and PD of these patients were measured and compared as initial, fourth and twelfth weeks. Solifenacin (n=140) significantly reduced IOP from 17.30±2.72 mmHg to 16.67±2.56 mmHg (p=0.006) and 16.57±2.41 mmHg (p=0.002), at the fourth and twelfth weeks, respectively. Darifenacin (n=110) significantly reduced NCT from 258.70±23.96 μm to 257.51±22.66 μm (p=0.002) and 255.36±19.69 μm (p=0.038), at the fourth and twelfth weeks, respectively. Submitted for publication: February 08, 2019 Accepted after revision: October 13, 2019 Published as Ahead of Print: November 30, 2019

INTRODUCTION

MATERIALS AND METHODS

Findings

DISCUSSION