Comparing the Relative Glomerular Filtration Rate with the Relative Renal Function Calculated by 99mTc-DMSA Static Scintigraphy

Abstract

Objective: To compare whether there is a statistical difference between the relative glomerular filtration rate (RGFR) obtained from renal dynamic imaging using 99mTc-DTPA and the relative renal function (RRF) obtained from renal static imaging using 99mTc-DMSA for children with urinary tract infection. Methods: We retrospectively analyzed 52 children with urinary tract infections, [31 females and 21 males, age: 3~168 months]. All patients underwent renal dynamic imaging with 99mTc-DTPA and renal static imaging with 99mTc-DMSA within one week period. RGFRs and RRFs were calculated for left and right kidneys. Wilcoxon Rank Sum Test is used for comparing the RGFR and RRF. Results: For 99mTc-DTPA renal dynamic imaging, the median and interquartile ranges of RGFRs are 52.55 (49.50, 57.98) for left kidneys and 47.45 (42.02, 50.50) for right kidneys. For 99mTc-DMSA renal static imaging, the values of RRFs are 52.20 (47.92, 57.31) for left kidneys and 47.80 (42.69, 52.08) for right kidneys. The RGFRs were statistically different from the RRFs in the groups of patients (Z =—2.377, P = 0.017). Conclusion: There exists statically difference between the relative glomerular filtration rate (RGFR) measured by renal dynamic imaging using 99mTc-DTPA and the relative renal function (RRF) measured by the renal static imaging using 99mTc-DMSA for the children with urinary tract infections.