Comparing the efficacy of lycopene & lycopene with hyaluronidase in management of oral sub mucous fibrosis-A clinical study

Abstract

Oral submucous fibrosis (OSMF) is a scarring disease of the oral cavity that develops over time. Lycopene is a potent antioxidant found in tomatoes that has the best singlet oxygen quenching capability and a strong capacity to quench other free radicals in vitro of all the dietary carotenoids. A protein called hyaluronidase, which is found in mammalian sperm and testes, hydrolyzes hyaluronic acid to alter the permeability of connective tissue.To determine the effectiveness of lycopene and lycopenehyaluronidase in treating OSMF, as well as a comparison of their effectiveness.: 45 people with OSMF were enrolled in the study and divided into three groups. Patients in Group A received two evenly divided doses of Lycored 16 mg twice daily for three months. Patients in Group B received LycoRed and a 1500 IU intralesional injection of hyaluronidase twice a week for three months. Patients in Group C received placebo pills. The patients were evaluated at the end of three months. We observed the opening of the mouth, visual examination, palpatory findings, and burning sensation.For lycopene and lycopene–hyaluronidase combination, there was a statistically significant difference in mouth opening and burning sensation compared to placebo.