Comparing the efficacy of intralesional triamcinolone acetonide and hyaluronidase with placental extract in oral submucous fibrosis cases: An original research

Abstract

Intralesional infiltrations with placental extract and triamcinolone with hyaluronidase are equally effective in treating trismus of OSMF. No difference in treatment efficacy was seen in placental extract group or with triamcinolone with hyaluronidase group. Oral submucous fibrosis is a widely prevalent oral mucosal lesion in Indian population and considering its premalignant potential and severe clinical manifestations many studies are done by many authors regarding various aspects of this condition such as etiology pathogenesis and treatment. Arecoline of Areca catechu is mostly attributed as the causative factors in addition to pan and tobacco in different combinations. In our study a random allocation of 120 patients was done equally into two groups. Group 1 received 4 ml of placental extract injection intralesionally at weekly interval for 12 weeks and Group 2 received combination of triamcinolone acetonide( 10 mg/ml) + hyaluronidase (1,500 IU) at weekly intervals for 12 weeks. Treatment outcome was evaluated on the basis of improvement in trismus, oral mucosal pattern and reduction in burning sensation.