Abstract
Introduction: Nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis. It is usually benign and gradually disappears with age. Objectives: This study was conducted on children with primary nocturnal enuresis to compare the efficacy of desmopressin and oxybutynin combination therapy with desmopressin monotherapy. Patients and Methods: This clinical trial was conducted on 59 patients (age range; 5 to 15 years) with primary nocturnal enuresis who had referred to our center in Tabriz in 2012. The participants were divided into two groups as group 1 (30 participants) and group 2 (29 subjects). For three months, one group received desmopressin and oxybutynin and the other group received desmopressin alone. Descriptive statistics (mean ± SD and frequency) and chi-square test was conducted. Results: In the group treated only with desmopressin, 72.4% of the participants were completely cured in 1 month and 44.8% in 3 months. In the group treated with combination of desmopressin and oxybutynin, 83.34% were cured in 1 month and 86.7% in 3 months. Conclusion: Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis.
Highlights
Nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis
Implication for health policy/practice/research/medical education: Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis
Patients and Methods This clinical trial was carried out on 59 patients with primary nocturnal enuresis who had referred to our center in Tabriz in 2012
Summary
Nocturnal enuresis is known as the most common developmental problems of childhood which has often a familial basis. Objectives: This study was conducted on children with primary nocturnal enuresis to compare the efficacy of desmopressin and oxybutynin combination therapy with desmopressin monotherapy. Conclusion: Desmopressin and oxybutynin combination therapy is more effective than desmopressin monotherapy for treating children with enuresis. Nocturnal enuresis is divided into two groups of mono-symptomatic and non-mono-symptomatic. Patient’s urination pattern, including frequency of urination during day and night, daytime incontinence and frequency of nocturnal enuresis in one week, is assessed. It is recommended to take desmopressin for three months, and if no response to treatment is observed, it can be considered as desmopressin resistant nocturnal enuresis. In 20% of the patients with nocturnal enuresis, this type of resistance is observed [13,14,15]
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