Abstract
Aims The purpose of this study was to compare the antifungal activity of sodium hypochlorite gel to those of four intracanal medicaments at various time intervals. Materials and Methods The agar well diffusion technique was utilized to test the antifungal activity of the following medicaments against Candida albinans (C. albicans): sodium hypochlorite gel, chlorhexidine gel, calcium hydroxide paste, Ledermix, and Diapex Plus. The inhibition zone related to each medicine was measured in millimeter after 24, 48, and 72 hours of incubation at 37°C. The data were analyzed using one-way ANOVA and Games–Howell tests, at a significance level of P < 0.05. Results Except for Ledermix and Diapex Plus, which had no antifungal action, all of the medicaments showed varied inhibitory zones for C. albicans. At all periods, the NaOCl gel had the most significant inhibition zones, followed by the CHX gel and calcium hydroxide. At all time intervals, the NaOCl gel demonstrated comparable antifungal efficacy. When compared to a 24-hour time interval, the CHX gel showed an increased antifungal activity at the 48-hour and 72-hour intervals. Calcium hydroxide, on the other hand, showed a decrease in its antifungal activity at the 72-hour interval. Conclusion The antifungal activity of sodium hypochlorite gel was the highest among the investigated medicaments. Chlorhexidine gel's antifungal activity improved over time, whereas calcium hydroxide's antifungal activity declined. Diapex Plus and Ledermix did not have any antifungal properties.
Highlights
Microorganisms are thought to be the primary cause of pulpal and periapical diseases [1]
Resistant bacteria might survive as a result of poor biomechanical instrumentation, inappropriate root canal filling, or reinfection by the microleakage process [3]. ese microorganisms are frequently responsible for the endodontic failure and the development of chronic periapical lesions [4]
The antifungal activity of sodium hypochlorite gel has never been studied to the best of our knowledge. erefore, the goal of this study was to examine and compare the antifungal efficacy of sodium hypochlorite gel to that of calcium hydroxide paste, chlorohexidine gel, Ledermix, and Diapex Plus against C. albicans using the agar well diffusion method at different time intervals. e null hypothesis for this study is that the antifungal effects of all examined medicaments against C. albicans are similar
Summary
Comparing the Antifungal Effect of Sodium Hypochlorite Gel versus Different Types of Root Canal Medicaments at Different Time Intervals Using the Agar Diffusion Test: An In Vitro Study. E purpose of this study was to compare the antifungal activity of sodium hypochlorite gel to those of four intracanal medicaments at various time intervals. E agar well diffusion technique was utilized to test the antifungal activity of the following medicaments against Candida albinans (C. albicans): sodium hypochlorite gel, chlorhexidine gel, calcium hydroxide paste, Ledermix, and Diapex Plus. The NaOCl gel had the most significant inhibition zones, followed by the CHX gel and calcium hydroxide. When compared to a 24-hour time interval, the CHX gel showed an increased antifungal activity at the 48-hour and 72-hour intervals. Diapex Plus and Ledermix did not have any antifungal properties
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