Abstract
Coronavirus disease 2019 (COVID-19) vaccination began for healthcare workers in South Korea at the end of February 2021. This study investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses after various COVID-19 vaccinations in healthcare workers. Blood specimens of 497 vaccinated healthcare workers were collected. Inoculated vaccines were ChAdOx1 (AstraZeneca/Oxford), BNT162b2 (Pfizer/BioNTech), JNJ-78436735 (Janssen), and mRNA-1273 (Moderna). Each specimen was tested for antibodies against SARS-CoV-2 using Elecsys Anti-SARS-CoV-2 S assay (Roche Diagnostics), SARS-CoV-2 IgG II Quant assay (Abbott), and R-FIND SARS-CoV-2 Neutralizing Antibody kit (SG medical Inc.). A questionnaire was used to investigate adverse events related to vaccination. We found that 99.5% of the subjects showed a 96–100% positive rate in all three antibody assays, regardless of the vaccine type. The antibody-positive rate of completed vaccination groups reached 96–100%, and antibody quantities significantly increased 2 weeks after vaccination. The antibody values measured approximately 3 months after BNT162b2 inoculation significantly correlated with adverse events.
Highlights
After the onset of global coronavirus disease 2019 (COVID-19) pandemic, vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed, and vaccination was started worldwide [1]
In 303 subjects who completed the ChAdOx1 vaccination, the difference in antibody amount was investigated for each elapsed period after the final injection (Figure 1)
There was no significant difference in antibody quantities in Elecsys Anti-SARS-CoV-2 assay over the entire period
Summary
After the onset of global coronavirus disease 2019 (COVID-19) pandemic, vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were developed, and vaccination was started worldwide [1]. To evaluate the effectiveness of vaccination, quantitative antibody detection should be conducted. In this regard, several studies have been conducted on the antibody figurequantities or antibody positive rate after vaccination [7,8,9,10,11,12]. Vaccination and the SARS-CoV-2 antibody detection test are uncommon in real-world clinical practice. It is necessary to conduct various studies and evaluate the effectiveness of vaccines to determine future vaccine policies. We measured the quantities of SARS-CoV-2 antibodies after vaccination in health care workers and analyzed the differences according to vaccine type and the elapsed days after vaccination. We investigated the relationship between adverse events and antibody quantities
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