Abstract
TO THE EDITOR: We read with interest the recently published work of Park et al. (10) examining differential regional control of sympathetic nerve activity in end-stage renal disease (ESRD). These investigators compared integrated multiunit recordings of muscle sympathetic nerve activity (MSNA) and skin sympathetic nerve activity (SSNA) at rest between patients with ESRD and healthy age- and gender-matched control subjects, using the technique of microneurography. Similar to previous reports, the ESRD patients demonstrated greater resting MSNA compared with controls. However, SSNA was similar between the two groups, leading the authors to conclude that “. . . although sympathetic activity directed to muscle is significantly elevated, activity directed to skin is not elevated in ESRD.” Although we commend the authors for addressing this important issue, there are major limitations in comparing basal SSNA between groups that should be considered, despite the work of others who have performed similar analyses (5, 8, 11).
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