Abstract
Concentrated growth factor (CGF) is an autogenuous product that contains highly concentrated number of platelets and can be derived from venous blood by selective centrifugation. It has been speculated that local growth factors in human platelets (insulinlike growth factor, IGF; transforming growth factor, TGF-b; platelet derived growth factor, PDGF) would enhance healing of grafts and also counteract resorption. The osteogensis effect of CGF and acellular dermal matrix (ADM) for alveolar cleft defects was evaluated in this study. Twenty alveolar cleft patients were divided randomly into two groups. One group underwent guided bone regeneration (GBR) using acellular dermal matrix film combined with alveolar bone grafting using iliac crest bone grafts (GBR group), while the other group underwent alveolar bone grafting combined with CGF (CGF group). Cone beam computed tomography (CBCT) images were obtained at 1 week and 6 months following the procedure. Using Mimics 17.0 software, the bone resorption rate and bone density improvement rate were calculated and compared between the two groups. Although not significant between ADM and CGF in bone resorption rate, the bone density improvement in cases with CGF(61.62 ± 4.728%) was much better than in cases with ADM (27.05 ± 5.607%) (p = 0.0002). Thus, CGF could be recommended to patients with alveolar cleft as a better choice.
Highlights
Alveolar bone grafting (ABG) in patients with cleft lip and palate has become an essential part of the surgical management of cleft lip and palate(CLP) patients
The patients were randomly divided into two groups, the group A (11 patients) received cancellous bone graft from the anterior iliac crest with Concentrated growth factor (CGF) while in the group B (9 patients), acellular dermal matrix (ADM) membrane was used during alveolar bone grafting
The bone resorption rate was no significance between the ADM group and the CGF group (p > 0.05) (Figure 2) .bone grafts with added CGF presented with increased bone density (61.62 ± 4.728%) in comparison to bone grafts with ADM (27.05 ± 5.607%) at end of 6-month postoperative
Summary
Alveolar bone grafting (ABG) in patients with cleft lip and palate has become an essential part of the surgical management of cleft lip and palate(CLP) patients. The key to the success of this operation is to effectively secure the bone grafts and prevent soft tissue and bacteria invasion into the bone regeneration zone, reducing complications such as bone resorption, infection, and dehiscence.[1] Various methods have been proposed to improve the process of ABG. The state of the art in-growth factor-aided tissue with regard to reconstruction have been proposed to be an adjuvant of ABG, which can enhance bone formation and to promote bone healing.
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